Wada J A, Mizoguchi T
Epilepsia. 1984 Jun;25(3):278-87. doi: 10.1111/j.1528-1157.1984.tb04190.x.
When forebrain-bisected photosensitive baboons, Papio papio, were kindled from the amygdala or hippocampus, bilateralization of convulsive seizure proved difficult, and the final stage of bisymmetrical and bisynchronous convulsive seizure unique to this species did not develop despite more than twice the number of kindling stimulations required for its development in nonbisected baboons. At the secondary site amygdala, convulsive seizure development was suppressed. Findings of the present and previous studies suggest that the corpus callosum plays: (a) a major, if not an exclusive, role in convulsive seizure bilateralization ; and (b) a critical role in the development of primarily generalized convulsive seizures unique to this epileptic baboon. Finally, in the absence of the corpus callosum (and the hippocampal commissure) the transhemisphere seizures suppressing effect generated by amygdaloid kindling appears to be mediated through the subcortical pathway which presumably exists in the brainstem.
当对前脑被切开的狒狒（豚尾狒狒）进行杏仁核或海马体点燃时，惊厥性癫痫发作的双侧化很难实现，尽管诱发该物种特有的双侧对称且同步的惊厥性癫痫发作最终阶段所需的点燃刺激次数是非切开狒狒的两倍多，但该阶段仍未发展出来。在次级位点杏仁核，惊厥性癫痫发作的发展受到抑制。本研究及先前研究的结果表明，胼胝体：(a) 在惊厥性癫痫发作双侧化中起主要作用（即便不是唯一作用）；(b) 在这种癫痫性狒狒特有的原发性全身性惊厥性癫痫发作的发展中起关键作用。最后，在没有胼胝体（以及海马连合）的情况下，杏仁核点燃产生的跨半球癫痫发作抑制作用似乎是通过脑干中可能存在的皮质下通路介导的。
