Chiang Tina H, Walt John G, McMahon John P, Mansfield James E, Simonyi Susan
Allergan Inc., Irvine, CA, USA.
Can J Clin Pharmacol. 2007 Summer;14(2):e240-5. Epub 2007 Jul 10.
Cyclosporine 0.05% ophthalmic emulsion (Restasis) is a treatment for dry eye disease.
To examine patients' cyclosporine 0.05% utilization patterns by analyzing prescription fill data.
A retrospective analysis with a large de-identified longitudinal patient database was conducted. Participants in the study had 1 prescription fill for cyclosporine 0.05% during a 3-month "enrollment" period from January 1 to March 31, 2004, and at least 1 refill within the following 12 months. Continuing patients had at least 1 cyclosporine 0.05% prescription fill, and new patients had none during 12 months prior to the "enrollment" period. Daily, monthly, and annual utilizations were assessed.
38,164 patients met the inclusion criteria. The majority of patients were female (82%), 50 years or older (77%), and new to therapy (59%). The FDA-recommended use is 2 vials daily (2 trays/month, each tray containing 32 vials) to receive the prescribed dosage of 1 drop in each eye twice daily. Prescription refill patterns demonstrated 73% of patients used 1 tray/month; similarly, 80% of the patients used 11 trays or less per year. Daily utilization differed between continuing and new patients. New patients had a bimodal use pattern. Over 30% were using > or = 1.75 vials/day and approximately 55% were using 0.25 to 1.25 vials/day. The majority of continuing patients (approximately 80%), however, used 0.25 to 1.25 vials/day.
Most patients used about 1 vial per day, less than the labeled 2 per day. The cost to managed care for cyclosporine 0.05% ophthalmic emulsion may be less than anticipated. Key words: Cyclosporine 0.05% ophthalmic emulsion, longitudinal patient database, cost, utilization.
0.05%环孢素眼用乳剂（Restasis）用于治疗干眼症。
通过分析处方配药数据来研究患者使用0.05%环孢素的模式。
对一个大量匿名的纵向患者数据库进行回顾性分析。研究参与者在从2004年1月1日至3月31日的3个月“入组”期间有1次0.05%环孢素的处方配药，且在接下来的12个月内至少有1次续方。持续用药患者有至少1次0.05%环孢素的处方配药，新患者在“入组”期前12个月内无用药记录。评估每日、每月和每年的用药情况。
38164名患者符合纳入标准。大多数患者为女性（82%），年龄在50岁及以上（77%），且为新接受治疗患者（59%）。美国食品药品监督管理局（FDA）推荐的用法是每日2瓶（每月2盘，每盘含32瓶），以达到每只眼每日滴2次、每次1滴的规定剂量。处方续方模式显示，73%的患者每月使用1盘；同样，80%的患者每年使用11盘或更少。持续用药患者和新患者的每日用药情况不同。新患者有双峰用药模式。超过30%的患者每日使用≥1.75瓶，约55%的患者每日使用0.25至1.25瓶。然而，大多数持续用药患者（约80%）每日使用0.25至1.25瓶。
大多数患者每日使用约1瓶，少于标签标注的每日2瓶。0.05%环孢素眼用乳剂的管理式医疗成本可能低于预期。关键词：0.05%环孢素眼用乳剂；纵向患者数据库；成本；用药情况
