低能量经瞳孔温热疗法联合玻璃体内注射曲安奈德治疗黄斑中心凹下脉络膜新生血管
Low-power transpupillary thermotherapy combined with intravitreal triamcinolone acetonide for subfoveal choroidal neovascularization.
作者信息
Zhang Xinyuan, Zhu Xiaoqing, Wang Dongsheng, Xu Liang, Jonas Jost B
机构信息
Beijing Institute of Ophthalmology, Department of Ophthalmology and Eye Hospital, Tongren Hospital, Capital University of Medical Science, Beijing, China.
出版信息
Ophthalmic Res. 2007;39(4):241-2. doi: 10.1159/000104833. Epub 2007 Jun 29.
PURPOSE
To examine transpupillary thermotherapy combined with intravitreal triamcinolone for treatment of subfoveal choroidal neovascularization.
METHODS
The clinical interventional, noncomparative, case series study included 14 patients (14 eyes) with choroidal neovascularization (age-related macular degeneration, n = 11; high myopia, n = 2; unknown reason, n = 1), who underwent transpupillary thermotherapy (75-150 mW, 60 s, 500-3,000 microm), followed by an intravitreal triamcinolone injection (10 mg). Follow-up was at least 6 months.
RESULTS
Visual acuity increased by 3 lines in 3 (21%) eyes at 3 months, and in 3 (21%) eyes at 6 months of follow-up. None of the patients experienced a visual acuity loss of 3 or more lines. At the 6-month follow-up, mean visual acuity was improved by 1.36 +/- 1.16 lines. Retreatment by transpupillary thermotherapy was performed for 3 (21%) eyes at 3 months, and for 1 (7%) eye at 6 months of follow-up.
CONCLUSIONS
Transpupillary thermotherapy combined with intravitreal triamcinolone may be a therapeutic option for choroidal neovascularization particularly if other treatment modalities are not available.
目的
探讨经瞳孔温热疗法联合玻璃体内注射曲安奈德治疗黄斑下脉络膜新生血管的疗效。
方法
本临床干预性、非对照性病例系列研究纳入了14例（14只眼）脉络膜新生血管患者（年龄相关性黄斑变性11例；高度近视2例；原因不明1例），接受经瞳孔温热疗法（75 - 150 mW，60秒，500 - 3000微米），随后玻璃体内注射曲安奈德（10毫克）。随访至少6个月。
结果
随访3个月时，3只眼（21%）视力提高3行，随访6个月时，3只眼（21%）视力提高3行。无患者视力下降3行或更多。在6个月随访时，平均视力提高1.36±1.16行。随访3个月时，3只眼（21%）接受了经瞳孔温热疗法再治疗，随访6个月时，1只眼（7%）接受了再治疗。
结论
经瞳孔温热疗法联合玻璃体内注射曲安奈德可能是脉络膜新生血管的一种治疗选择，尤其是在没有其他治疗方式可用时。
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