Spector Logan G, Ross Julie A, Puumala Susan E, Roesler Michelle, Olshan Andrew F, Bunin Greta R
Division of Epidemiology/Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA.
Am J Epidemiol. 2007 Oct 1;166(7):852-6. doi: 10.1093/aje/kwm143. Epub 2007 Jul 10.
As random digit dialing becomes increasingly unfeasible for many types of studies, alternative methods for control selection are needed, especially for studies of childhood cancer. US birth registries are an appealing source of young control children because they are population based, provide demographic and pregnancy data for comparison of participants with the study base, and maintain data that enable matching on birth characteristics. Here the authors describe the ability of US birth registries to release information sufficient to locate potential control subjects for two ongoing case-control studies of hepatoblastoma and infant leukemia. The birth registries of 32 states, in which 75.8% of US children 0-5 years of age resided in 2004, agreed to participate in control selection. Data sufficient to track participants and to characterize nonrespondents were available from a majority of registries. These results suggest that birth registries may be used to select controls for studies of rare childhood diseases on a national scale.
随着随机数字拨号对于许多类型的研究变得越来越不可行，需要有替代的对照选择方法，尤其是对于儿童癌症的研究。美国出生登记处是年幼对照儿童的一个有吸引力的来源，因为它们基于人群，提供人口统计学和妊娠数据以便将参与者与研究基础进行比较，并且保存能够根据出生特征进行匹配的数据。在此，作者描述了美国出生登记处为两项正在进行的肝母细胞瘤和婴儿白血病病例对照研究提供足以找到潜在对照对象的信息的能力。2004年，美国32个州的出生登记处同意参与对照选择，美国0至5岁儿童中有75.8%居住在这些州。大多数登记处都有足以追踪参与者并描述无回应者特征的数据。这些结果表明，出生登记处可用于在全国范围内为罕见儿童疾病的研究选择对照。
