Cockburn Ian A, Zavala Fidel
Department of Molecular Microbiology and Immunology, Johns Hopkins Malaria Research Institute, Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA.
Curr Opin Immunol. 2007 Aug;19(4):424-9. doi: 10.1016/j.coi.2007.05.008. Epub 2007 Jul 12.
The observation that individuals living in malaria endemic areas fail to develop sterilizing immunity to malaria infection has led to the assumption that malaria-specific immune responses are sub-optimal. Recently, T cell receptor (TCR) transgenic mice specific for the sporozoite and blood stages of the malaria parasite have been developed. Studies using these models have found that, unexpectedly, T cell memory in malaria is not noticeably defective. However, if T cell memory is 'normal' why are people not better protected? We suggest this is because protective immunity and T cell memory do not always correlate; moreover, T cells alone may simply not be able to provide the type of antibody-mediated sterilizing immunity induced by traditional vaccines.
生活在疟疾流行地区的个体未能对疟疾感染产生无菌免疫，这一观察结果导致人们认为针对疟疾的免疫反应不够理想。最近，已培育出针对疟原虫子孢子和血液阶段的T细胞受体（TCR）转基因小鼠。使用这些模型的研究意外地发现，疟疾中的T细胞记忆并无明显缺陷。然而，如果T细胞记忆“正常”，为什么人们没有得到更好的保护呢？我们认为这是因为保护性免疫和T细胞记忆并不总是相关的；此外，仅T细胞可能根本无法提供传统疫苗所诱导的那种抗体介导的无菌免疫。
