树突状细胞可以启动针对疟疾的保护性免疫反应。
Dendritic cells can initiate protective immune responses against malaria.
作者信息
Bruña-Romero O, Rodriguez A
机构信息
Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York 10010, USA.
出版信息
Infect Immun. 2001 Aug;69(8):5173-6. doi: 10.1128/IAI.69.8.5173-5176.2001.
Abstract
An understanding of the antigen presentation mechanisms that mediate induction of protective immune responses against malaria is essential for the development of successful immunization approaches. Here we show that dendritic cells presenting Plasmodium yoelii sporozoite antigens are able to activate specific CD4(+) and CD8(+) T cells and initiate protective immune responses against malaria in mice.
摘要
了解介导针对疟疾诱导保护性免疫反应的抗原呈递机制，对于成功开发免疫方法至关重要。在此我们表明，呈递约氏疟原虫子孢子抗原的树突状细胞能够激活特定的CD4(+)和CD8(+) T细胞，并在小鼠中引发针对疟疾的保护性免疫反应。
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