尤登指数与质量为零的标志物的最佳阈值。
Youden Index and the optimal threshold for markers with mass at zero.
作者信息
Schisterman Enrique F, Faraggi David, Reiser Benjamin, Hu Jessica
机构信息
Division of Epidemiology, Statistics and Prevention, NICHD, NIH, Rockville, MD, USA.
出版信息
Stat Med. 2008 Jan 30;27(2):297-315. doi: 10.1002/sim.2993.
Abstract
The Youden Index is often used as a summary measure of the receiver operating characteristic curve. It measures the effectiveness of a diagnostic marker and permits the selection of an optimal threshold value or cutoff point for the biomarker of interest. Some markers, while basically continuous and positive, have a spike or positive mass of probability at the value zero. We provide a flexible modeling approach for estimating the Youden Index and its associated cutoff point for such spiked data and compare it with the standard empirical approach. We show how this modeling approach can be adjusted to take covariate information into account. This approach is applied to data on the Coronary Calcium Score, a marker for atherosclerosis.
摘要
尤登指数常被用作接收者操作特征曲线的一种汇总指标。它衡量诊断标志物的有效性，并允许为感兴趣的生物标志物选择最佳阈值或临界点。一些标志物虽然本质上是连续且为正的，但在值为零时具有一个尖峰或概率正质量。我们提供一种灵活的建模方法来估计此类尖峰数据的尤登指数及其相关临界点，并将其与标准经验方法进行比较。我们展示了如何调整这种建模方法以考虑协变量信息。该方法应用于冠状动脉钙化评分的数据，冠状动脉钙化评分是动脉粥样硬化的一个标志物。
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