Gortner Ludwig
University Children's Hospital, University of the Saarland, Germany.
J Perinat Med. 2007;35(5):361-5. doi: 10.1515/JPM.2007.082.
Intrauterine growth restriction (IUGR) has been demonstrated to have serious consequences for health in adult age. These include an increased risk for metabolic syndrome, pulmonary and cardiovascular disorders. These disorders are in part secondary to the development of arterial hypertension, which has been demonstrated to be more frequent in individuals subjected to restricted intrauterine growth.
A review on publications on pathogenesis and epidemiology of hypertension associated to IUGR.
Current concepts for this association include a reduced nephrogenesis and increased arterial stiffness, impaired sympathetic regulation and steroid metabolism secondary to IUGR. Early postnatal risk-modifying factors include among others catch-up growth leading to childhood overweight.
IUGR increases the risk of hypertension in adult life. Identifying relevant risk factors for arterial hypertension will be the basis for the development of preventive concepts to be applied for predisposed individuals.
宫内生长受限（IUGR）已被证明会对成年后的健康产生严重后果。这些后果包括代谢综合征、肺部和心血管疾病的风险增加。这些疾病部分继发于动脉高血压的发展，而动脉高血压在宫内生长受限的个体中更为常见。
对有关IUGR相关高血压发病机制和流行病学的出版物进行综述。
这种关联的当前概念包括肾发生减少和动脉僵硬度增加、交感神经调节受损以及IUGR继发的类固醇代谢异常。出生后早期的风险修正因素包括追赶生长导致儿童超重等。
IUGR增加了成年后患高血压的风险。识别动脉高血压的相关风险因素将是为易感个体制定预防方案的基础。
