Schreuder Michiel F, van Wijk Joanna A E, Delemarre-van de Waal Henriette A
Department of Pediatrics, The Netherlands.
J Hypertens. 2006 Jul;24(7):1337-43. doi: 10.1097/01.hjh.0000234114.33025.fd.
Intrauterine growth restriction (IUGR) is associated with a higher risk of hypertension in adulthood. In Western countries, IUGR is based on uteroplacental dysfunction. We hypothesize that aging augments the increased baseline blood pressure after IUGR and alters the cardiovascular response to acute stress.
To evaluate blood pressure during aging in the rat, we used a model of uteroplacental dysfunction (bilateral uterine artery ligation). Blood pressure was measured in male offspring at the ages of 6, 9, and 12 months using telemetry, allowing for unstressed measurements in conscious animals. At 6 and 12 months of age, cardiovascular data were obtained during acute olfactory stress induced by ammonia and subsequent recovery.
Rats born after IUGR had lower birth weights (4.6 versus 6.5 g, P < 0.001) and did not completely catch up in weight by 12 months of age (519 versus 567 g, P < 0.01). Systolic blood pressure was significantly higher in IUGR animals at all ages. Pulse pressure (PP) was identical in both groups at the age of 6 months. However, PP increased in the IUGR group with increasing age, unlike the control group, and was significantly higher at 9 and 12 months of age. At the age of 12 months, there was a highly significant negative correlation between birth weight and PP (r = -0.82, P < 0.001). IUGR rats reached a higher peak in systolic blood pressure during stress, and showed a longer period for the raised heart rate to recover after stress.
IUGR is associated with raised baseline blood pressure, an increasing PP with age, and an altered stress response.
宫内生长受限（IUGR）与成年后患高血压的风险较高相关。在西方国家，IUGR是基于子宫胎盘功能障碍。我们假设衰老会加剧IUGR后基线血压的升高，并改变心血管对急性应激的反应。
为了评估大鼠衰老过程中的血压，我们使用了子宫胎盘功能障碍模型（双侧子宫动脉结扎）。使用遥测技术在雄性后代6、9和12月龄时测量血压，从而能够在清醒动物中进行无应激状态下的测量。在6和12月龄时，在由氨气诱导的急性嗅觉应激及其后的恢复过程中获取心血管数据。
IUGR后出生的大鼠出生体重较低（4.6克对6.5克，P<0.001），到12月龄时体重未完全追赶上来（519克对567克，P<0.01）。IUGR动物在所有年龄段的收缩压均显著较高。两组在6月龄时脉压（PP）相同。然而，与对照组不同，IUGR组的PP随年龄增长而增加，在9和12月龄时显著更高。在12月龄时，出生体重与PP之间存在高度显著的负相关（r = -0.82，P<0.001）。IUGR大鼠在应激期间收缩压达到更高峰值，且应激后心率升高恢复所需时间更长。
IUGR与基线血压升高、PP随年龄增加以及应激反应改变相关。
