Trindade Daniel C, Trindade Raquel C, Marassi Michelle P, Martins Ornélia P P R, Costa-e-Sousa Ricardo H, Mattos Elisabete C, Marinho Alcides, Reis Luís C, Olivares Emerson L
Universidade de Barra Mansa, Barra Mansa, RJ, 27330-550, Brazil.
An Acad Bras Cienc. 2007 Jun;79(2):251-9. doi: 10.1590/s0001-37652007000200008.
We investigated the morphologic and functional changes of infarcted rat hearts under a paradigm of angiotensinconverting enzyme inhibition. Myocardial infarction was induced by left coronary artery ligation and a control group (SHAM) underwent sham-operation. Infarcted rats received normal drinking water with (CAP group) or without (INF group) captopril. Functional assessment was performed by electro (ECG) and echocardiogram (ECHO) just before and 21 days after surgery. The ECG of INF and CAP showed similar values and resembled healed infarct after surgery. The most outstanding differences between INF and CAP were the prevention of the increase of P-wave and attenuation both in rightward deviation of the QRS axis and Q-wave amplitude in CAP compared with INF. The ECHO showed that captopril treatment improved the diastolic filling more than systolic performance. Cardiac dilatation and left congestive heart failure were observed only in INF. Both infarcted groups showed a scar tissue in the left ventricular wall, but the INF showed a higher scar area than CAP (49.7+/-5.24 vs. 22.33+/-6.19 respectively). These data suggest that the renin-angiotensin system induces morphologic and functional changes in post-infarcted rat hearts and which can be assessed by non-invasive exams.
我们在血管紧张素转换酶抑制模式下研究了梗死大鼠心脏的形态和功能变化。通过结扎左冠状动脉诱导心肌梗死，对照组（假手术组）进行假手术。梗死大鼠饮用含卡托普利（卡托普利组）或不含卡托普利（梗死组）的正常饮用水。在手术前及手术后21天通过心电图（ECG）和超声心动图（ECHO）进行功能评估。梗死组和卡托普利组的心电图值相似，术后类似愈合的梗死情况。梗死组和卡托普利组之间最显著的差异在于，与梗死组相比，卡托普利组可预防P波增高，并减轻QRS电轴右偏和Q波振幅。超声心动图显示，卡托普利治疗对舒张期充盈的改善大于收缩期功能。仅在梗死组观察到心脏扩张和左心充血性心力衰竭。两个梗死组在左心室壁均显示有瘢痕组织，但梗死组的瘢痕面积高于卡托普利组（分别为49.7±5.24和22.33±6.19）。这些数据表明，肾素-血管紧张素系统可诱导梗死大鼠心脏发生形态和功能变化，且可通过非侵入性检查进行评估。
