Zimmer Julia, Hawlitschek Christina, Rabald Steffen, Hagendorff Andreas, Zimmer Heinz-Gerd, Rassler Beate
Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany.
Department of Anesthesiology and Intensive Care Medicine, University of Leipzig, Leipzig, Germany.
Hypertens Res. 2015 Nov;38(11):716-22. doi: 10.1038/hr.2015.68. Epub 2015 Jul 16.
The purpose of the present study was to analyze the changes in blood pressure, left ventricular (LV) wall thickness and LV systolic function of aged spontaneously hypertensive rats (SHRs) either with or without antihypertensive therapy. Twenty-one SHRs aged 60.5±0.25 weeks were investigated over 22 weeks. They were divided into the following three groups (7 per group): untreated controls (CTRL), treatment with captopril (CAP, 60 mg kg(-1) daily) and treatment with captopril plus nifedipine (CAP+NIF, 60+10 mg kg(-1) daily). Systolic blood pressure (SBP) was regularly measured using the tail cuff method, and an echocardiogram was repeatedly obtained to examine the LV systolic and diastolic area, LV systolic fractional area change, cardiac output and LV myocardial wall thickness. Finally, heart catheterization was performed. While SBP remained stable in the CTRL animals over the experimental period, both of the antihypertensive treatments significantly reduced SBP by 20% in the treated animals (P<0.001). Echocardiography demonstrated that both the systolic and the diastolic LV function of the untreated SHRs deteriorated over time, whereas both types of antihypertensive treatments attenuated and delayed but did not completely prevent the decline in LV systolic function. Cardiac output, as determined by pulsed wave Doppler echocardiography, remained significantly higher in the treated animals than in CTRLs until week 20, but it then decreased. Heart catheterization showed a significant decrease in LV function, as reflected by the LV systolic pressure and contractility, in the CTRLs but not in treated animals. These findings clearly indicate that late-onset antihypertensive treatment with CAP or CAP+NIF is beneficial with respect to blood pressure reduction, LV hypertrophy attenuation and LV systolic function preservation.
本研究的目的是分析接受或未接受抗高血压治疗的老年自发性高血压大鼠（SHR）的血压、左心室（LV）壁厚度和左心室收缩功能的变化。对21只年龄为60.5±0.25周的SHR进行了为期22周的研究。它们被分为以下三组（每组7只）：未治疗对照组（CTRL）、卡托普利治疗组（CAP，每日60mg/kg）和卡托普利加硝苯地平治疗组（CAP+NIF，每日60+10mg/kg）。使用尾袖法定期测量收缩压（SBP），并反复进行超声心动图检查以检测左心室收缩和舒张面积、左心室收缩分数面积变化、心输出量和左心室心肌壁厚度。最后，进行心脏导管插入术。在实验期间，CTRL组动物的SBP保持稳定，而两种抗高血压治疗均使治疗组动物的SBP显著降低了20%（P<0.001）。超声心动图显示，未治疗的SHR的左心室收缩和舒张功能均随时间恶化，而两种抗高血压治疗均减轻并延迟了左心室收缩功能的下降，但并未完全阻止其下降。通过脉冲波多普勒超声心动图测定的心输出量在第20周之前，治疗组动物仍显著高于CTRL组，但随后下降。心脏导管插入术显示，CTRL组动物的左心室功能显著下降，表现为左心室收缩压和收缩性降低，而治疗组动物则未出现这种情况。这些发现清楚地表明，CAP或CAP+NIF的晚期抗高血压治疗在降低血压、减轻左心室肥厚和保留左心室收缩功能方面是有益的。
