Matsuoka Oscar Tadashi, Shibao Simone, Leone Cléa Rodrigues
Neonadal and Clinical Pediatrics Division, Children's Institute, Nursery Annex of the Maternity of the Clinics Hospital of the São Paulo, University Medical School, São Paulo, Brazil.
Sao Paulo Med J. 2007 Mar 1;125(2):85-90. doi: 10.1590/s1516-31802007000200004.
Low birth weight is associated with higher blood pressure in childhood and adulthood. The aim of this study was to investigate the influence of intrauterine growth restriction (IUGR) on newborn systolic blood pressure (SBP).
Prospective comparative study at Neonatal and Intensive in Clinical Pediatrics Division, Maternity Hospital in Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo.
35 newborns with IUGR and 35 without IUGR were compared. Healthy term newborns without malformations, with Apgar score at fifth minute > 6 were included. Birth weight, kidney weight/birth weight ratio, kidney weight (ultrasound scan), plasma renin activity (PRA) and SBP evolution were analyzed during the first month of life (on 1st, 3rd, 7th and 30th days).
SBP evolution, kidney weight/birth weight ratio and PRA did not differ between the two groups. In newborns with IUGR, SBP presented positive correlations with birth weight (r = 0.387 p = 0.026) and BMI (r = 0.412 p = 0.017) on the 7th day of life. Positive correlations with birth weight (r = 0.440 p = 0.01) and birth length (r = 0.386 p = 0.026) were also seen on the 30th day. There was an inverse correlation on the 7th day between SBP and kidney weight/birth weight ratio (r = -0.420 p = 0.014), but this did not persist to the end of the month.
IUGR seems not to have any influence on SBP, PRA or kidney weight among term newborns during their first month of life.
低出生体重与儿童期及成年期较高的血压相关。本研究旨在探讨宫内生长受限（IUGR）对新生儿收缩压（SBP）的影响。
圣保罗大学医学院临床医院妇产科新生儿及重症监护科的前瞻性对照研究。
比较35例IUGR新生儿和35例非IUGR新生儿。纳入无畸形、出生后第5分钟阿氏评分>6分的健康足月儿。分析出生后第1个月（第1、3、7和30天）的出生体重、肾脏重量/出生体重比值、肾脏重量（超声扫描）、血浆肾素活性（PRA）及SBP变化。
两组间SBP变化、肾脏重量/出生体重比值及PRA无差异。在IUGR新生儿中，出生后第7天SBP与出生体重（r = 0.387，p = 0.026）及体重指数（r = 0.412，p = 0.017）呈正相关。出生后第30天，SBP与出生体重（r = 0.440，p = 0.01）及出生身长（r = 0.386，p = 0.026）也呈正相关。出生后第7天，SBP与肾脏重量/出生体重比值呈负相关（r = -0.420，p = 0.014），但至月末这种相关性未持续存在。
在足月儿出生后的第1个月，IUGR似乎对SBP、PRA或肾脏重量无任何影响。
