Król Marzenna, Florek Ewa, Kornacka Maria K, Bokiniec Renata, Piekoszewski Wojciech
Klinika Neonatologii i Intensywnej Terapii, Noworodka Uniwersytet Medyczny, Warszawa.
Przegl Lek. 2009;66(10):548-53.
The aim of this work was the assessment of the clinical condition, birth weight, frequency of premature birth and incidence of intrauterine growth restriction (IUGR) of the newborns whose mothers were active and passive smokers. This was a prospective study conducted in a group of 147 newborns born during the years 2003-2004 in the Princess Anna Mazowiecka Hospital, Warsaw, and hospitalized in the Neonatal and Intensive Care Department of Warsaw Medical University. Based on a questionnaire identifying the exposure to tobacco smoke and cotinine concentration in the mother's urine, the newborns were assigned to three groups: the newborns whose mothers were active smokers, the newborns whose mothers were passive smokers and the newborns of non-smoking mothers. There were no statistically significant differences in the Apgar score assessment at the 1st and 5th minute between the three groups of the newborns. Acid-base balance parameters (pH, BE) were also similar. The birth weight of the newborns of mothers who were active smokers was 325g lower than the birth weight of the newborns of non-smoking mothers. This difference was statistically significant p = 0.033. Maternal smoking in pregnancy was associated with an increased risk of deficit in birth weight 2.6 (1.0-6.9, CI 95%). In the group of the newborns whose mothers were active smokers, the incidence of lower birth weight (< 2500g) was also statistically significantly higher p = 0.01. There were no statistically significant differences in the incidence of premature birth and intrauterine growth restriction (IUGR).
这项研究的目的是评估母亲为主动吸烟者和被动吸烟者的新生儿的临床状况、出生体重、早产频率及宫内生长受限（IUGR）的发生率。这是一项前瞻性研究，研究对象为2003年至2004年期间在华沙安娜·马佐维茨卡公主医院出生并在华沙医科大学新生儿及重症监护科住院的147名新生儿。根据一份确定母亲接触烟草烟雾情况及母亲尿液中可替宁浓度的调查问卷，将新生儿分为三组：母亲为主动吸烟者的新生儿、母亲为被动吸烟者的新生儿和母亲不吸烟的新生儿。三组新生儿在出生第1分钟和第5分钟时的阿氏评分评估无统计学显著差异。酸碱平衡参数（pH值、碱剩余）也相似。母亲为主动吸烟者的新生儿出生体重比母亲不吸烟的新生儿低325克。这一差异具有统计学显著性，p = 0.033。孕期母亲吸烟与出生体重不足风险增加相关，风险比为2.6（1.0 - 6.9，95%置信区间）。在母亲为主动吸烟者的新生儿组中，低出生体重（< 2500克）的发生率也具有统计学显著性升高，p = 0.01。早产和宫内生长受限（IUGR）的发生率无统计学显著差异。
