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[头孢唑林钠滴眼液在不同溶液中的稳定性]

[Stability of cefazolin sodium as eyedrops in various solutions].

作者信息

Yildirim N, Topbaş S, Usluer G, Ozgüneş I, Başmak H, Yurdakul S

机构信息

Anadolu Universitesi, Tip Fakültesi, Göz Hastaliklari Anabilim Dali Oğretim Uyesi.

出版信息

Mikrobiyol Bul. 1991 Jul;25(3):272-6.

PMID:1762595
Abstract

Cephazolin sodium prepared with four different solutions (NaCl 0.9%, Protagent, Liquifilm and phosphate buffer) to be used as eye drops, was evaluated as to its physicochemical features at +4 degrees C, +37 degrees C and at room temperature and its activity in terms of minimal inhibition concentration. In conclusion, cephazolin sodium prepared with artificial tears at acidic pH can be kept for 3 days at room temperature and at +4 degrees C without any loss of its activity.

摘要

用四种不同溶液(0.9%氯化钠溶液、Protagent、Liquifilm和磷酸盐缓冲液)配制用作眼药水的头孢唑林钠,在4℃、37℃和室温下对其理化特性进行了评估,并就其最低抑菌浓度测定了活性。总之,用酸性pH值的人工泪液配制的头孢唑林钠在室温及4℃下可保存3天,其活性无任何损失。

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