Koskiniemi Marjaleena, Lappalainen Maija, Schmid D Scott, Rubtcova Elena, Loparev Vladimir N
Haartman Institute, Department of Virology, University of Helsinki, P.O. Box 21 (Haartmaninkatu 3), Helsinki, Finland.
Clin Vaccine Immunol. 2007 Sep;14(9):1057-61. doi: 10.1128/CVI.00348-06. Epub 2007 Jul 11.
We evaluated the seroprevalence of varicella-zoster virus (VZV) in the Finnish population among various age groups and genetically characterized VZV strains from documented cases of varicella and zoster. VZV-specific immunoglobulin G was measured in 2,842 serum samples that had been submitted for virological studies to the Department of Virology, University of Helsinki, from 1995 to 1996. Specimens for VZV genotyping were obtained from vesicular lesions from two pediatric patients and 26 adult patients. Seroprevalence to VZV varied markedly by age: 45% in children aged < or = 2 months, 12.5% in children aged 6 to 8 months, and > 90% in children near 10 years of age, plateauing thereafter into advanced age. The seroprevalence rates indicate that in Finland, as in other countries with temperate climates, primary VZV infection usually occurs during the first decade of life. Twenty-eight VZV DNA-positive specimens were analyzed to identify VZV vaccine and wild-type genotypes. All analyzed specimens were wild type and the European (E) genotype.
我们评估了芬兰人群中不同年龄组水痘带状疱疹病毒（VZV）的血清流行率，并对水痘和带状疱疹确诊病例中的VZV毒株进行了基因特征分析。1995年至1996年期间，对提交至赫尔辛基大学病毒学系进行病毒学研究的2842份血清样本检测了VZV特异性免疫球蛋白G。从两名儿科患者和26名成年患者的水疱性皮损中获取了用于VZV基因分型的样本。VZV的血清流行率随年龄显著变化：2个月及以下儿童中为45%，6至8个月儿童中为12.5%，10岁左右儿童中超过90%，此后直至老年保持稳定。血清流行率表明，在芬兰，与其他气候温和的国家一样，原发性VZV感染通常发生在生命的第一个十年。对28份VZV DNA阳性样本进行分析以鉴定VZV疫苗株和野生型基因型。所有分析样本均为野生型且为欧洲（E）基因型。
