Cohen D I, Davidovici B B, Smetana Z, Balicer R D, Klement E, Mendelson E, Green M S
Department of Epidemiology and Preventive Medicine, Tel Aviv University, Sackler Faculty of Medicine, Tel Aviv, Israel.
Infection. 2006 Aug;34(4):208-13. doi: 10.1007/s15010-006-6604-4.
This large-scale study provides up-to-date estimates of Varicella zoster virus (VZV) age-specific seroprevalence and characteristics of VZV transmission in a representative sample of the Israeli population.
In 2000-2001, 1,642 sera collected from an agestratified general population sample were tested for VZV antibodies using an indirect IgG ELISA system.
The age-weighted VZV overall estimate was 90.2%. Seropositivity increased rapidly with age, from 68.9% at age 4 to 94.4% at age 7 and 96.6% at age 12 years. The highest force of infection was in the 4-5 years age group (0.548 per susceptible year) followed by the 6-9 years age group. Multivariate analysis revealed that VZV seroprevalence estimates were significantly associated with age and place of origin. The highest seroprevalence estimate was found among subjects of Eastern origin.
The seroepidemiology of VZV in Israel shows a pattern corresponding to that described for developed European countries. This study indicates that the highest force of infection is in pre-school children. Knowledge of pre-vaccination seroepidemiology is important to evaluate the effect of vaccination programs on the epidemiology of the disease.
这项大规模研究提供了以色列人群代表性样本中水痘带状疱疹病毒（VZV）按年龄划分的血清流行率的最新估计值以及VZV传播特征。
在2000 - 2001年，使用间接IgG ELISA系统对从年龄分层的普通人群样本中收集的1642份血清进行VZV抗体检测。
年龄加权的VZV总体估计值为90.2%。血清阳性率随年龄迅速上升，从4岁时的68.9%升至7岁时的94.4%以及12岁时的96.6%。最高感染强度出现在4 - 5岁年龄组（每年每易感个体0.548），其次是6 - 9岁年龄组。多变量分析显示，VZV血清流行率估计值与年龄和出生地显著相关。在东方裔受试者中发现最高的血清流行率估计值。
以色列VZV的血清流行病学呈现出与欧洲发达国家描述的模式相对应的情况。这项研究表明最高感染强度出现在学龄前儿童中。接种疫苗前血清流行病学知识对于评估疫苗接种计划对该疾病流行病学的影响很重要。
