Prasad C, Hilton C W, Lohr J B, Robertson H J
Department of Medicine, Louisiana State University Medical Center, New Orleans 70112.
Neuropeptides. 1991 Nov;20(3):187-90. doi: 10.1016/0143-4179(91)90130-b.
Cyclo(His-Pro) (CHP) is a peptide endogenous to human brain and cerebrospinal fluid (CSF). In animal studies administration of exogenous CHP augments dopaminergic neurotransmission. To explore the role of this peptide in schizophrenia, a disease characterized by a hyperdopaminergic state, we have measured CSF CHP levels in control, never-medicated schizophrenics and medicated schizophrenics. Our data show a 53% increase in CSF levels of CHP in never-medicated schizophrenics (p = 0.015), and a 25% increase in medicated schizophrenics when compared to controls. We speculate that CHP may contribute to the expression of hyperdopaminergic symptoms in schizophrenia.
环（组氨酸-脯氨酸）（CHP）是一种人类大脑和脑脊液（CSF）中的内源性肽。在动物研究中，给予外源性CHP可增强多巴胺能神经传递。为了探究这种肽在精神分裂症（一种以多巴胺能状态亢进为特征的疾病）中的作用，我们测量了对照组、未用药的精神分裂症患者和用药的精神分裂症患者脑脊液中的CHP水平。我们的数据显示，未用药的精神分裂症患者脑脊液中CHP水平增加了53%（p = 0.015），与对照组相比，用药的精神分裂症患者增加了25%。我们推测，CHP可能促成了精神分裂症中多巴胺能亢进症状的表现。
