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Transient forebrain ischemia of three-minute duration consistently induces severe neuronal damage in field CA1 of the hippocampus in the normothermic gerbil.

作者信息

Mitani A, Andou Y, Masuda S, Kataoka K

机构信息

Department of Physiology, School of Medicine, Ehime University, Japan.

出版信息

Neurosci Lett. 1991 Oct 14;131(2):171-4. doi: 10.1016/0304-3940(91)90606-t.

Abstract

We examined the effect of transient forebrain ischemia of 2-, 3-, 4- and 5-min duration on the development of delayed neuronal death in field CA1 of the hippocampus in the gerbil whose brain temperature was maintained at 37 degrees C. Transient ischemia of 3- and 4-min duration caused almost the same maximal damage in field CA1 as observed in the gerbils subjected to 5-min ischemia. A detrimental factor inducing delayed neuronal death in field CA1 may be already set up during the first 3 min after the onset of ischemia in the gerbil whose brain temperature is maintained at normothermic levels.

摘要

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