Moreno-Romero J A, Segura S, Mascaró J M, Cowper S E, Julià M, Poch E, Botey A, Herrero C
Department of Dermatology, Hospital Clinic de Barcelona, Universitat de Barcelona, Villarroel 170, Barcelona 08036, Spain.
Br J Dermatol. 2007 Oct;157(4):783-7. doi: 10.1111/j.1365-2133.2007.08067.x. Epub 2007 Jul 11.
Nephrogenic systemic fibrosis (NSF) or nephrogenic fibrosing dermopathy is a rare fibrotic condition that presents in patients with a history of renal disease. The aetiology is unknown, but it has recently been proposed that gadolinium, a paramagnetic contrast agent, may be a trigger of this disease. We report three patients with NSF with a history of use of gadolinium in magnetic resonance angiography a few weeks before the onset of symptoms. In the future, gadolinium should probably be avoided as much as possible in renal insufficiency patients until its role in the development of NSF is clarified.
肾源性系统性纤维化（NSF）或肾源性纤维性皮肤病是一种罕见的纤维化病症，见于有肾脏疾病史的患者。病因不明，但最近有人提出，顺磁性造影剂钆可能是这种疾病的触发因素。我们报告了3例NSF患者，他们在症状出现前几周有在磁共振血管造影中使用钆的病史。未来，在肾功能不全患者中，可能应尽可能避免使用钆，直到其在NSF发病中的作用得到阐明。
