Wagner Brent, Drel Viktor, Gorin Yves
South Texas Veterans Health Care System, San Antonio, Texas; and University of Texas Health Science Center at San Antonio, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F1-F11. doi: 10.1152/ajprenal.00166.2016. Epub 2016 May 4.
Systemic fibrosis from gadolinium-based magnetic resonance imaging contrast is a scourge for the afflicted. Although gadolinium-associated systemic fibrosis is a rare condition, the threat of litigation has vastly altered clinical practice. Most theories concerning the etiology of the fibrosis are grounded in case reports rather than experiment. This has led to the widely accepted conjecture that the relative affinity of certain contrast agents for the gadolinium ion inversely correlates with the risk of succumbing to the disease. How gadolinium-containing contrast agents trigger widespread and site-specific systemic fibrosis and how chronicity is maintained are largely unknown. This review highlights experimentally-derived information from our laboratory and others that pertain to our understanding of the pathophysiology of gadolinium-associated systemic fibrosis.
基于钆的磁共振成像造影剂引发的全身性纤维化对患者来说是一场灾难。尽管钆相关的全身性纤维化是一种罕见病症，但诉讼威胁已极大地改变了临床实践。大多数关于纤维化病因的理论都基于病例报告而非实验。这导致了一种被广泛接受的推测，即某些造影剂对钆离子的相对亲和力与患该病的风险呈负相关。含钆造影剂如何引发广泛且特定部位的全身性纤维化以及纤维化如何持续存在在很大程度上尚不清楚。本综述重点介绍了来自我们实验室及其他机构的实验性信息，这些信息与我们对钆相关全身性纤维化病理生理学的理解有关。
