Molecular associations of vitamin E.

To understand how vitamin E fulfills its functions in membranes and lipoproteins, it is necessary to know how it associates with the lipid components of these structures and the effects its presence has on their structure and stability. Studies of model membrane systems containing vitamin E have proved to be an informative approach to address these questions. A review of the way vitamin E interacts with phospholipid bilayers, how it distributes within the structure, its motional diffusion characteristics, and orientation has been undertaken. The effect of vitamin E on membrane stability and permeability has been described. The tendency of vitamin E to form complexes with certain phospholipids is examined as is the way modulation of protein functions takes place. Finally, recent evidence relevant to the putative role of vitamin E in protecting membranes from free radical attack and the consequences of lipid oxidation in lipoproteins and membranes is examined.