Calzada Fernando, Yépez-Mulia Lilian, Tapia-Contreras Amparo
Unidad de Investigación Médica en Farmacología de Productos Naturales, UMAE Hospital de Pediatría, 2 Piso, Centro Médico Nacional Siglo XXI, IMSS, Av. Cuauhtemoc 330, Col. Doctores, CP 06725, México D.F., Mexico.
J Ethnopharmacol. 2007 Sep 5;113(2):248-51. doi: 10.1016/j.jep.2007.06.001. Epub 2007 Jun 7.
Crude methanolic extracts from 22 Mexican medicinal plants were screened for antitrichomonal activity against Trichomonas vaginalis, which is the etiological agent of trichomoniasis. Among the plants tested Carica papaya and Cocos nucifera showed the best antitrichomonal activity with IC(50) values of 5.6 and 5.8 microg/ml, respectively. The extracts of Bocconia frutescens, Geranium mexicanum, and Lygodium venustum showed moderate activity with IC(50) values ranging from 30.9 to 60.9 microg/ml. All the other plant extracts were inactive (IC(50)>100 microg/ml). All extracts tested were less active than metronidazole (IC(50) 0.037 microg/ml), an antiprotozoal drug used as positive control. The results of the antiprotozoal screening support the popular uses of five of the plants tested for the treatment of some urogenital tract disorders in Mexican traditional medicine. However, seeds of Carica papaya and aerial parts of Bocconia frutescens should be used in herbal medicine with care to avoid toxicity.
对22种墨西哥药用植物的粗甲醇提取物进行了抗阴道毛滴虫活性筛选，阴道毛滴虫是滴虫病的病原体。在所测试的植物中，番木瓜和椰子表现出最佳的抗滴虫活性，IC（50）值分别为5.6和5.8微克/毫升。博落回、墨西哥老鹳草和美丽乌巢蕨的提取物表现出中等活性，IC（50）值在30.9至60.9微克/毫升之间。所有其他植物提取物均无活性（IC（50）>100微克/毫升）。所有测试提取物的活性均低于作为阳性对照的抗寄生虫药物甲硝唑（IC（50）0.037微克/毫升）。抗寄生虫筛选结果支持了墨西哥传统医学中所测试的五种植物在治疗某些泌尿生殖道疾病方面的广泛应用。然而，番木瓜种子和博落回地上部分在草药中应谨慎使用，以避免毒性。
