Norman Ross M G, Malla Ashok K, Manchanda Rahul
University of Western Ontario and Prevention and Early Intervention Program for Psychoses, WMCH Building, 392 South Street, London, Ontario, Canada N6A 4G5.
Schizophr Res. 2007 Sep;95(1-3):111-4. doi: 10.1016/j.schres.2007.06.007. Epub 2007 Jul 12.
Shorter duration of untreated psychosis (DUP) is often correlated with a poorer response to treatment. In this paper we test the hypothesis that the importance of DUP is moderated by early premorbid adjustment.
Three year prospective data were collected for 154 first episode patients. DUP, premorbid adjustment and symptoms were assessed at time of presentation for treatment and symptoms were reassessed after three years of treatment.
DUP was correlated with level of symptoms at three years only for patients with better premorbid adjustment in childhood and early adolescence.
These results suggest that DUP may have more of an impact on treatment response for those with a less pernicious, more reversible form of illness.
未治疗精神病持续时间（DUP）较短通常与治疗反应较差相关。在本文中，我们检验了DUP的重要性受病前早期适应调节这一假设。
收集了154例首发患者的三年前瞻性数据。在开始治疗时评估DUP、病前适应和症状，并在治疗三年后重新评估症状。
仅在童年期和青春期早期病前适应较好的患者中，DUP与三年后的症状水平相关。
这些结果表明，DUP可能对病情较轻、更具可逆性的患者的治疗反应有更大影响。
