Pitsikas Nikolaos, Sakellaridis Nikolaos
Department of Pharmacology, School of Medicine, University of Thessaly, 22, Papakiriazi str., 412-22 Larissa, Greece.
Eur J Pharmacol. 2007 Oct 1;571(2-3):174-9. doi: 10.1016/j.ejphar.2007.06.019. Epub 2007 Jun 27.
The effects of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist memantine on recognition memory were investigated in the rat by using the object recognition task. In addition, a possible interaction between memantine and the nitric oxide (NO) donor molsidomine in antagonizing extinction of recognition memory was also evaluated utilizing the same behavioral procedure. In a first dose-response study, post-training administration of memantine (10 and 20, but not 3 mg/kg) antagonized recognition memory deficits in the rat, suggesting that memantine modulates storage and/or retrieval of information. In a subsequent study, combination of sub-threshold doses of memantine (3 mg/kg) and the NO donor molsidomine (1 mg/kg) counteracted delay-dependent impairments in the same task. Neither memantine (3 mg/kg) nor molsidomine (1 mg/kg) alone reduced object recognition performance deficits. The present findings indicate a) that memantine is involved in recognition memory and b) support a functional interaction between memantine and molsidomine on recognition memory mechanisms.
通过物体识别任务，在大鼠中研究了非竞争性N-甲基-D-天冬氨酸（NMDA）受体拮抗剂美金刚对识别记忆的影响。此外，还利用相同的行为程序评估了美金刚与一氧化氮（NO）供体吗多明在拮抗识别记忆消退方面可能存在的相互作用。在第一项剂量反应研究中，训练后给予美金刚（10和20mg/kg，但3mg/kg无效）可拮抗大鼠的识别记忆缺陷，这表明美金刚可调节信息的存储和/或检索。在随后的一项研究中，阈下剂量的美金刚（3mg/kg）与NO供体吗多明（1mg/kg）联合使用可抵消同一任务中与延迟相关的损伤。单独使用美金刚（3mg/kg）或吗多明（1mg/kg）均不能降低物体识别性能缺陷。目前的研究结果表明：a）美金刚参与识别记忆；b）支持美金刚与吗多明在识别记忆机制上存在功能相互作用。
