Baruch Susannah, Kaufman David, Hudson Kathy L
Genetics and Public Policy Center, Berman Institute of Bioethics of Johns Hopkins University, Washington, DC.
Genetics and Public Policy Center, Berman Institute of Bioethics of Johns Hopkins University, Washington, DC.
Fertil Steril. 2008 May;89(5):1053-1058. doi: 10.1016/j.fertnstert.2007.05.048. Epub 2007 Jul 12.
To better understand the current practices of IVF clinics regarding preimplantation genetic diagnosis (PGD) and explore the attitudes and opinions of clinic directors toward PGD.
On-line Survey of 415 assisted reproductive technology (ART) clinics in the United States. The Survey had a valid response rate of 45% (186 clinics).
Not applicable.
PATIENT(S): Respondents were medical directors, laboratory directors, IVF directors, or directors' designees of ART clinics offering IVF.
INTERVENTION(S): Not applicable.
MAIN OUTCOME MEASURE(S): Practices and beliefs of IVF clinic directors with respect to PGD.
RESULT(S): Preimplantation genetic diagnosis is widely provided for a variety of indications, and clinic directors support professional guidelines to guide PGD in the future.
CONCLUSION(S): Preimplantation genetic diagnosis is an established technology and medical procedure offered by a majority of US IVF clinics. Many clinics currently provide PGD for controversial indications such as sex selection. Although there is little support for government regulation of PGD, there is significant support among IVF clinics for strong professional guidelines for PGD practice. Ongoing collection of data on PGD practice and outcomes would help patients make informed decisions and aid professionals in developing appropriate guidelines and standards.
更好地了解体外受精（IVF）诊所目前在植入前基因诊断（PGD）方面的做法，并探讨诊所主任对PGD的态度和看法。
对美国415家辅助生殖技术（ART）诊所进行在线调查。该调查的有效回复率为45%（186家诊所）。
不适用。
受访者为提供IVF的ART诊所的医学主任、实验室主任、IVF主任或主任指定人员。
不适用。
IVF诊所主任关于PGD的做法和信念。
植入前基因诊断广泛应用于多种适应症，诊所主任支持未来指导PGD的专业指南。
植入前基因诊断是一项既定技术和医疗程序，大多数美国IVF诊所都提供。目前许多诊所将PGD用于性别选择等有争议的适应症。尽管几乎没有支持政府对PGD进行监管，但IVF诊所中对PGD实践的强有力专业指南有很大支持。持续收集PGD实践和结果的数据将有助于患者做出明智的决定，并帮助专业人员制定适当的指南和标准。
