Baruch Susannah, Kaufman David J, Hudson Kathy L
From the Genetics and Public Policy Center, Berman Institute of Bioethics, Johns Hopkins University, Washington DC, USA.
Genet Med. 2008 Sep;10(9):685-90. doi: 10.1097/gim.0b013e31818180a1.
The purpose of this study was to determine which US in vitro fertilization clinics provide preimplantation genetic screening for aneuploidy in treating infertility, and to explore clinic directors' attitudes toward this technique.
Online survey included 415 US assisted reproductive technology clinics. The survey had a valid response rate of 45% or 186 clinics.
Nearly 68% of US in vitro fertilization clinics responding to the survey provided preimplantation genetic screening in an effort to increase success rates of fertility treatment. More than half of these in vitro fertilization clinics (56%) provided preimplantation genetic screening for advanced maternal age and the same percentage provided preimplantation genetic screening to treat repeated in vitro fertilization failure, whereas 66% provided preimplantation genetic screening to treat women with repeated miscarriage. Opinions of the effectiveness of preimplantation genetic screening for these indications varied widely, even among those providing it. Most directors (85%) of clinics providing preimplantation genetic screening believed that more data are needed to determine whether and to whom it should be offered.
Despite the lack of data supporting the use of preimplantation genetic screening for recurrent pregnancy loss, in vitro fertilization failure, and advanced maternal age, a majority of in vitro fertilization clinics in the United States offer preimplantation genetic screening for these purposes. There is significant support among clinic directors for more research into the effectiveness of preimplantation genetic screening and for professional guidelines in this area.
本研究旨在确定美国哪些体外受精诊所为治疗不孕症提供非整倍体植入前基因筛查，并探讨诊所主任对该技术的态度。
在线调查涵盖了415家美国辅助生殖技术诊所。该调查的有效回复率为45%，即186家诊所。
参与调查的美国体外受精诊所中，近68%提供植入前基因筛查，以提高生育治疗的成功率。这些体外受精诊所中，超过一半（56%）为高龄产妇提供植入前基因筛查，同样比例的诊所为治疗反复体外受精失败提供该筛查，而66%的诊所为治疗反复流产的女性提供植入前基因筛查。对于这些适应症的植入前基因筛查效果，即使在提供该筛查的诊所中，意见也存在很大差异。提供植入前基因筛查的诊所的大多数主任（85%）认为，需要更多数据来确定是否应该提供以及应该向谁提供该筛查。
尽管缺乏数据支持将植入前基因筛查用于复发性流产、体外受精失败和高龄产妇，但美国大多数体外受精诊所仍出于这些目的提供植入前基因筛查。诊所主任们大力支持对植入前基因筛查的有效性进行更多研究，并支持该领域的专业指南。
