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A U1 snRNA binding site improves the efficiency of in vitro pre-mRNA splicing.

作者信息

Kreivi J P, Zerivitz K, Akusjärvi G

机构信息

Department of Microbial Genetics, Karolinska Institute, Stockholm, Sweden.

出版信息

Nucleic Acids Res. 1991 Dec 25;19(24):6956. doi: 10.1093/nar/19.24.6956.

DOI:10.1093/nar/19.24.6956
PMID:1762927
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC329340/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e307/329340/cb53598777fc/nar00104-0266-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e307/329340/cb53598777fc/nar00104-0266-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e307/329340/cb53598777fc/nar00104-0266-a.jpg

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The U1 snRNP protein U1C recognizes the 5' splice site in the absence of base pairing.U1 snRNP蛋白U1C在不存在碱基配对的情况下识别5'剪接位点。
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U1 snRNA is cleaved by RNase III and processed through an Sm site-dependent pathway.U1 小核核糖核酸（snRNA）被核糖核酸酶 III 切割，并通过一条依赖 Sm 位点的途径进行加工。
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The conserved AU dinucleotide at the 5' end of nascent U1 snRNA is optimized for the interaction with nuclear cap-binding-complex.新生U1小核RNA 5'端保守的AU二核苷酸经过优化，以利于与核帽结合复合物相互作用。
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U2 toggles iteratively between the stem IIa and stem IIc conformations to promote pre-mRNA splicing.U2在茎IIa和茎IIc构象之间反复切换，以促进前体mRNA剪接。
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本文引用的文献

1
Exon definition may facilitate splice site selection in RNAs with multiple exons.外显子定义可能有助于具有多个外显子的RNA中剪接位点的选择。
Mol Cell Biol. 1990 Jan;10(1):84-94. doi: 10.1128/mcb.10.1.84-94.1990.
2
Sequences involved in the control of adenovirus L1 alternative RNA splicing.
Nucleic Acids Res. 1991 May 11;19(9):2379-86. doi: 10.1093/nar/19.9.2379.
EMBO J. 2022 Jan 4;41(1):e107640. doi: 10.15252/embj.2021107640. Epub 2021 Nov 15.
4
The adenovirus L4-22K protein regulates transcription and RNA splicing via a sequence-specific single-stranded RNA binding.腺病毒L4-22K蛋白通过序列特异性单链RNA结合来调节转录和RNA剪接。
Nucleic Acids Res. 2017 Feb 28;45(4):1731-1742. doi: 10.1093/nar/gkw1145.
5
Increased Serine-Arginine (SR) Protein Phosphorylation Changes Pre-mRNA Splicing in Hypoxia.丝氨酸 - 精氨酸（SR）蛋白磷酸化增加改变缺氧状态下的前体mRNA剪接。
J Biol Chem. 2015 Jul 17;290(29):18079-18089. doi: 10.1074/jbc.M115.639690. Epub 2015 May 28.
6
A targeted oligonucleotide enhancer of SMN2 exon 7 splicing forms competing quadruplex and protein complexes in functional conditions.一种靶向SMN2外显子7剪接的寡核苷酸增强剂在功能条件下形成竞争性四链体和蛋白质复合物。
Cell Rep. 2014 Oct 9;9(1):193-205. doi: 10.1016/j.celrep.2014.08.051. Epub 2014 Sep 25.
7
Splicing of internal large exons is defined by novel cis-acting sequence elements.内部大外显子的剪接由新的顺式作用序列元件定义。
Nucleic Acids Res. 2012 Oct;40(18):9244-54. doi: 10.1093/nar/gks652. Epub 2012 Jul 11.
8
Regulation of alternative RNA splicing by exon definition and exon sequences in viral and mammalian gene expression.病毒和哺乳动物基因表达中通过外显子定义和外显子序列对可变RNA剪接的调控。
J Biomed Sci. 2004 May-Jun;11(3):278-94. doi: 10.1007/BF02254432.
9
Functional selection of splicing enhancers that stimulate trans-splicing in vitro.在体外刺激反式剪接的剪接增强子的功能筛选。
RNA. 2001 Jun;7(6):793-805. doi: 10.1017/s1355838201010524.
10
Utilization of the bovine papillomavirus type 1 late-stage-specific nucleotide 3605 3' splice site is modulated by a novel exonic bipartite regulator but not by an intronic purine-rich element.1型牛乳头瘤病毒晚期特异性核苷酸3605的3'剪接位点的利用受一种新型外显子双组分调节因子调控，而非受内含子富含嘌呤元件的调控。
J Virol. 2000 Nov;74(22):10612-22. doi: 10.1128/jvi.74.22.10612-10622.2000.