来自地衣节松萝的扁枝衣酸衍生物及其抗氧化活性。
Stictic acid derivatives from the lichen Usnea articulata and their antioxidant activities.
作者信息
Lohézic-Le Dévéhat Françoise, Tomasi Sophie, Elix John A, Bernard Aurélie, Rouaud Isabelle, Uriac Philippe, Boustie Joël
机构信息
Institut de Chimie de Rennes, EA 4090 Substances Lichéniques et Photoprotection, Faculté de Pharmacie, Université de Rennes, 2 Avenue du Professeur Léon Bernard, 35043 Rennes Cedex, France.
出版信息
J Nat Prod. 2007 Jul;70(7):1218-20. doi: 10.1021/np070145k. Epub 2007 Jul 13.
Two new beta-orcinol depsidones, 1 and 2, together with 13 known compounds were isolated from the lichen Usnea articulata. The structures of 1 and 2 were elucidated by spectroscopic analyses and those of known compounds by comparison of their spectroscopic data with literature values or by direct comparison with authentic standards. Compounds 1, 2, and 5 exhibited moderate antiradical activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. The depsidones 4 and 5 showed better superoxide anion scavenging activity (IC50 = 566 and 580 microM, respectively) than quercetin (IC50 = 754 microM).
从地衣节松萝中分离得到了两种新的β-苔黑酚缩酚酸酮，化合物1和2，以及13种已知化合物。通过光谱分析阐明了化合物1和2的结构，通过将已知化合物的光谱数据与文献值进行比较或与标准品直接比较来确定其结构。在1,1-二苯基-2-苦基肼（DPPH）试验中，化合物1、2和5表现出中等程度的抗自由基活性。缩酚酸酮4和5的超氧阴离子清除活性（IC50分别为566和580微摩尔）比槲皮素（IC50 = 754微摩尔）更好。
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