利用单线态氧通过氟化物辅助将功能化呋喃区域选择性转化为α-取代的γ-羟基丁烯内酯
Fluoride-assisted regioselective conversion of functionalized furans to alpha-substituted gamma-hydroxybutenolides using singlet oxygen.
作者信息
Patil Santoshkumar N, Liu Fei
机构信息
Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.
出版信息
J Org Chem. 2007 Aug 3;72(16):6305-8. doi: 10.1021/jo070666c. Epub 2007 Jul 13.
PMID:17629339
Abstract
A facile synthesis of alpha-substituted gamma-hydroxybutenolides from 3-furfural was achieved using a Baylis-Hillman reaction followed by singlet oxygen oxidation. The regioselectivity of this conversion was controlled by using TBAF.
摘要
通过Baylis-Hillman反应，然后进行单线态氧氧化，实现了从3-糠醛轻松合成α-取代的γ-羟基丁烯内酯。该转化的区域选择性通过使用四丁基氟化铵（TBAF）来控制。
Zotero 插件