Morgan M S
Royal Devon & Exeter Foundation Trust, Barrack Road, Exeter EX2 5DW, UK.
Int J Antimicrob Agents. 2007 Oct;30(4):289-96. doi: 10.1016/j.ijantimicag.2007.04.019. Epub 2007 Jul 12.
Panton-Valentine leukocidin (PVL)-producing Staphylococcus aureus is emerging as a serious problem worldwide. Whilst usually causing skin and soft-tissue infections, particularly recurrent abscesses, there has in the last 10 years been an increase in the incidence of an associated devastating pneumonia affecting previously healthy young people and associated with a very high mortality. There are no evidence-based guidelines to consult for the management of PVL-associated staphylococcal pneumonia. The literature contains less than 100 cases, with widely differing antimicrobial therapies and the occasional use of other adjunctive therapies such as intravenous immunoglobulin, activated protein C and extracorporeal membrane oxygenation. This literature review focuses on the salient features of diagnosis and management, with particular attention to the choice of antimicrobials.
产杀白细胞素（PVL）的金黄色葡萄球菌正在成为全球范围内的一个严重问题。虽然它通常引起皮肤和软组织感染，尤其是复发性脓肿，但在过去10年中，一种相关的毁灭性肺炎的发病率有所上升，这种肺炎影响以前健康的年轻人，且死亡率很高。目前尚无基于证据的指南可用于指导PVL相关葡萄球菌肺炎的管理。文献中报道的病例不到100例，抗菌治疗方法差异很大，偶尔还会使用其他辅助治疗，如静脉注射免疫球蛋白、活化蛋白C和体外膜肺氧合。这篇文献综述重点关注诊断和管理的显著特征，尤其关注抗菌药物的选择。
