[正电子发射断层扫描与计算机断层扫描联合成像在 Erdheim-Chester 病中的应用价值]

[Usefulness of combined positron emission tomography and computed tomography imaging in Erdheim-Chester disease].

作者信息

Girszyn N, Arnaud L, Villain D, Kahn J-E, Piette A-M, Bletry O

机构信息

Service de médecine interne, hôpital Foch, 40, rue Worth, 92151 Suresnes cedex, France.

出版信息

Rev Med Interne. 2007 Nov;28(11):770-4. doi: 10.1016/j.revmed.2007.05.036. Epub 2007 Jun 27.

DOI:10.1016/j.revmed.2007.05.036

PMID:17629593

Abstract

INTRODUCTION

Erdheim-Chester disease is a rare non-Langerhans form of histiocytosis. We report the use of combined fluorodeoxyglucose positron emission tomography and computed tomography (18F-FDG PET-CT) in this disease.

EXEGESIS

Three men, aged from 55 to 74 years with confirmed Erdheim-Chester disease were included. 18F-FDG PET-CT allowed to detect visceral and vascular involvement of the disease which were overlooked with CT-scan or magnetic resonance imaging: left common carotid and ilio-femoral artery in one patient, coronary, femoral and tibia in the second, aortic, common carotid, femoral and mandibula in the remaining patient. Also, sequential 18F-FDG PET-CT was useful to appreciate treatment efficiency (decrease hyperfixation) and decide treatment modification (interferon alpha).

CONCLUSION

18F-FDG PET-CT combined imaging allows to assess the extent of involvement in Erdheim-Chester disease. 18F-FDG PET-CT may be also a useful tool in the management of Erdheim-Chester disease.

摘要

引言

厄尔德海姆-切斯特病是一种罕见的非朗格汉斯组织细胞增多症。我们报告了氟脱氧葡萄糖正电子发射断层扫描与计算机断层扫描联合检查（18F-FDG PET-CT）在该疾病中的应用。

注释

纳入了3名年龄在55至74岁之间确诊为厄尔德海姆-切斯特病的男性患者。18F-FDG PET-CT能够检测出该疾病的内脏和血管受累情况，而这些情况在CT扫描或磁共振成像中被遗漏：1例患者累及左颈总动脉和髂股动脉；第2例累及冠状动脉、股动脉和胫骨；其余1例累及主动脉、颈总动脉、股动脉和下颌骨。此外，连续的18F-FDG PET-CT有助于评估治疗效果（减少高摄取）并决定治疗方案的调整（使用α干扰素）。