老年人的合理用药：其测量与优化效果如何？

Appropriate prescribing in elderly people: how well can it be measured and optimised?

作者信息

Spinewine Anne, Schmader Kenneth E, Barber Nick, Hughes Carmel, Lapane Kate L, Swine Christian, Hanlon Joseph T

机构信息

Center for Clinical Pharmacy, School of Pharmacy, Université catholique de Louvain, Brussels, Belgium.

Aging Center and Department of Medicine (Geriatrics), School of Medicine, Duke University Medical Center, Durham, NC, USA; Geriatric Research Education and Clinical Center, Veterans Affairs Medical Center, Durham, NC, USA.

出版信息

Lancet. 2007 Jul 14;370(9582):173-184. doi: 10.1016/S0140-6736(07)61091-5.

DOI:10.1016/S0140-6736(07)61091-5

PMID:17630041

Abstract

Prescription of medicines is a fundamental component of the care of elderly people, and optimisation of drug prescribing for this group of patients has become an important public-health issue worldwide. Several characteristics of ageing and geriatric medicine affect medication prescribing for elderly people and render the selection of appropriate pharmacotherapy a challenging and complex process. In the first paper in this series we aim to define and categorise appropriate prescribing in elderly people, critically review the instruments that are available to measure it and discuss their predictive validity, critically review recent randomised controlled intervention studies that assessed the effect of optimisation strategies on the appropriateness of prescribing in elderly people, and suggest directions for future research and practice.

摘要

药物处方是老年人护理的一个基本组成部分，优化这组患者的药物处方已成为全球重要的公共卫生问题。衰老和老年医学的几个特征影响着老年人的药物处方，并使选择合适的药物治疗成为一个具有挑战性和复杂性的过程。在本系列的第一篇论文中，我们旨在定义和分类老年人的合理处方，严格审查可用于衡量它的工具并讨论其预测效度，严格审查最近评估优化策略对老年人处方合理性影响的随机对照干预研究，并提出未来研究和实践的方向。