McMurtray Aaron, Nakamoto Beau, Shikuma Cecelia, Valcour Victor
Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96816, USA.
Cerebrovasc Dis. 2007;24(2-3):236-41. doi: 10.1159/000104484. Epub 2007 Jun 28.
This study is designed to determine the relationship between age and occurrence of cerebral manifestations of small-vessel ischemic vascular disease in human immunodeficiency virus (HIV)-seropositive individuals.
Periventricular leukoaraiosis severity and white matter lesion volume were determined by magnetic resonance imaging of the brain of 57 HIV-seropositive individuals.
Cerebral small-vessel ischemic vascular disease manifestations correlated with age and systolic blood pressure, but not with HIV infection-related parameters.
These findings suggest that, in the era of highly active antiretroviral therapy, leukoaraiosis severity and white matter lesion volume may be more indicative of small-vessel ischemic vascular disease than HIV-related CNS pathology, and support the need for aggressive treatment of vascular risk factors in HIV-seropositive individuals.
本研究旨在确定人类免疫缺陷病毒（HIV）血清反应阳性个体的年龄与小血管缺血性血管病脑表现发生之间的关系。
通过对57名HIV血清反应阳性个体的脑部进行磁共振成像，确定脑室周围白质疏松症的严重程度和白质病变体积。
脑小血管缺血性血管病表现与年龄和收缩压相关，但与HIV感染相关参数无关。
这些发现表明，在高效抗逆转录病毒治疗时代，白质疏松症严重程度和白质病变体积可能比HIV相关的中枢神经系统病理学更能指示小血管缺血性血管病，并支持对HIV血清反应阳性个体积极治疗血管危险因素的必要性。
