Gruber Stephen B, Moreno Victor, Rozek Laura S, Rennerts Hedy S, Lejbkowicz Flavio, Bonner Joseph D, Greenson Joel K, Giordano Thomas J, Fearson Eric R, Rennert Gad
Department of Internal Medicine, University of Michigan Medical School, 109 Zina Pitcher, Ann Arbor, Michigan 48109, USA.
Cancer Biol Ther. 2007 Jul;6(7):1143-7. doi: 10.4161/cbt.6.7.4704.
Chromosome 8q24 harbors oncogenes known to be involved in pathogenesis of colorectal cancer (CRC) as well as uncharacterized genetic variants that have recently been shown to influence inherited risk of prostate cancer. In a population-based case-control study of colorectal cancer in northern Israel, we investigated the association between variation in 8q24 and risk of CRC. Among 1,861 incident cases and 1,937 population-based controls matched on age, gender, ethnicity, and clinic, rs10505477 was associated with risk of CRC in a dominant model, with an odds ratio = 1.23, 95% confidence interval = 1.05-1.43, (p = 0.008). This association was independently validated in an analysis of cancer among relatives of carriers of the risk allele, with a hazard ratio of 3.2 (95% bootstrap CI = 1.16-17.8). Genetic variation at rs10505477 on 8q24 potentially accounts for 14% of CRC in this population and should be replicated in other studies.
8号染色体q24区域含有已知与结直肠癌（CRC）发病机制相关的致癌基因，以及最近显示会影响前列腺癌遗传风险的未表征遗传变异。在以色列北部一项基于人群的结直肠癌病例对照研究中，我们调查了8q24区域变异与结直肠癌风险之间的关联。在1861例新发病例和1937例按年龄、性别、种族和诊所匹配的人群对照中，rs10505477在显性模型中与结直肠癌风险相关，比值比 = 1.23，95%置信区间 = 1.05 - 1.43，（p = 0.008）。在对风险等位基因携带者亲属的癌症分析中，该关联得到独立验证，风险比为3.2（95%自展置信区间 = 1.16 - 17.8）。8q24区域rs10505477的遗传变异可能占该人群结直肠癌的14%，应在其他研究中进行重复验证。
