Tong Yu, Wang Huiqing, Li Shiping, Zhao Fengyan, Ying Junjie, Qu Yi, Mu Dezhi
Department of Pediatrics Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Medicine (Baltimore). 2018 Aug;97(35):e11990. doi: 10.1097/MD.0000000000011990.
Genome-wide association studies (GWAS) have identified multiple independent cancer susceptibility loci at chromosome 8q24.We conducted a comprehensive research synopsis and meta-analysis to evaluate associations between 6 variants in 8q24 and risk of colorectal cancer using data from 31 eligible articles totaling 41,942 cases and 49,968 controls.Of the 6 variants located in 8q24, 3 were significantly associated with risk of colorectal cancer. In particular, both homozygous TT and heterozygous CT genotypes of rs10505477, as well as the GG and TG genotypes of rs6983267, were associated with risk of colorectal cancer.Our study provides summary evidence that common variants in the 8q24 are associated with risk of colorectal cancer in this large-scale research synopsis and meta-analysis. Further studies are needed to explore the exact role of the variants in the 8q24 involved in the etiology of colorectal cancer.
全基因组关联研究（GWAS）已在8号染色体长臂2区4带（8q24）鉴定出多个独立的癌症易感基因座。我们进行了一项全面的研究综述和荟萃分析，利用来自31篇符合条件的文章的数据（共41942例病例和49968例对照），评估8q24区域6个变体与结直肠癌风险之间的关联。在位于8q24的6个变体中，有3个与结直肠癌风险显著相关。特别是，rs10505477的纯合子TT和杂合子CT基因型，以及rs6983267的GG和TG基因型，均与结直肠癌风险相关。我们的研究提供了总结性证据，即在这项大规模研究综述和荟萃分析中，8q24区域的常见变体与结直肠癌风险相关。需要进一步研究以探索8q24区域的变体在结直肠癌病因学中的确切作用。
