Akpa Belinda S, Matthews Sinéad M, Sederman Andrew J, Yunus Kamran, Fisher Adrian C, Johns Michael L, Gladden Lynn F
Department of Chemical Engineering, University of Cambridge, New Museums Site, Pembroke Street, Cambridge CB2 3RA, UK.
Anal Chem. 2007 Aug 15;79(16):6128-34. doi: 10.1021/ac070364a. Epub 2007 Jul 14.
Magnetic resonance imaging (MRI) is a noninvasive technique that can be used to visualize mixing processes in optically opaque systems in up to three dimensions. Here, MRI has been used for the first time to obtain both cross-sectional velocity and concentration maps of flow through an optically opaque Y-shaped microfluidic sensor. Images of 23 micromx23 microm resolution were obtained for a channel of rectangular cross section (250 micromx500 microm) fed by two square inlets (250 micromx250 microm). Both miscible and immiscible liquid systems have been studied. These include a system in which the coupling of flow and mass transfer has been observed, as the diffusion of the analyte perturbs local hydrodynamics. MRI has been shown to be a versatile tool for the study of mixing processes in a microfluidic system via the multidimensional spatial resolution of flow and mass transfer.
磁共振成像（MRI）是一种非侵入性技术，可用于在高达三维的光学不透明系统中可视化混合过程。在此，MRI首次用于获取通过光学不透明Y形微流体传感器的流动的横截面速度和浓度图。对于由两个方形入口（250微米×250微米）进料的矩形横截面通道（250微米×500微米），获得了分辨率为23微米×23微米的图像。对互溶和不互溶液体系统均进行了研究。其中包括一个观察到流动与传质耦合的系统，因为分析物的扩散会扰乱局部流体动力学。通过流动和传质的多维空间分辨率，MRI已被证明是研究微流体系统中混合过程一种通用工具。
