Rose U
Institut für Pharmazie, Johannes-Gutenberg-Universität Mainz.
Pharm Acta Helv. 1991;66(3):68-9.
The symmetrically substituted dihydropyridine-dicarboxylate 3 exerts only weak calcium antagonistic activity on smooth muscles compared with the standard nifedipine. On electrically stimulated, left guinea pig-atria and particularly on electrically stimulated papillary muscles marked positive inotropic effects are registered. They can be attributed to release of catecholamines from intracellular stores.
与标准硝苯地平相比，对称取代的二氢吡啶 - 二羧酸酯3对平滑肌仅表现出微弱的钙拮抗活性。在电刺激的豚鼠左心房，特别是在电刺激的乳头肌上，可记录到明显的正性肌力作用。这些作用可归因于细胞内储存的儿茶酚胺的释放。
