Bartlett E J, Wolkin A, Brodie J D, Laska E M, Wolf A P, Sanfilipo M
Department of Psychiatry, New York University Medical Center, NY 10016.
Psychiatry Res. 1991 Oct;40(2):115-24. doi: 10.1016/0925-4927(91)90003-9.
This study compares the effects of two neuroleptic drugs with different pharmacologic characteristics (thiothixene and haloperidol) on cerebral glucose utilization in chronic schizophrenic inpatients. Positron emission tomographic (PET) scans were obtained from all subjects in a neuroleptic-free condition and again after 4-6 weeks of neuroleptic treatment. Eight subjects were treated with thiothixene and 12 with haloperidol. Thiothixene and haloperidol had different metabolic effects. For example, all thiothixene-treated subjects showed increased whole brain glucose utilization; all but one haloperidol-treated subject showed decreased utilization. Different patterns of relative prefrontal and striatal metabolism were also observed. These results highlight the importance of controlling for the effects of neuroleptic treatment and indicate the difficulty of interpreting data from studies with complex or poorly defined drug regimens.
本研究比较了两种具有不同药理学特性的抗精神病药物（硫利达嗪和氟哌啶醇）对慢性精神分裂症住院患者脑葡萄糖利用的影响。在所有受试者处于未服用抗精神病药物状态时以及抗精神病药物治疗4 - 6周后，均进行了正电子发射断层扫描（PET）。8名受试者接受硫利达嗪治疗，12名接受氟哌啶醇治疗。硫利达嗪和氟哌啶醇具有不同的代谢效应。例如，所有接受硫利达嗪治疗的受试者全脑葡萄糖利用均增加；除一名接受氟哌啶醇治疗的受试者外，其他所有受试者的葡萄糖利用均降低。还观察到前额叶和纹状体相对代谢的不同模式。这些结果突出了控制抗精神病药物治疗效果的重要性，并表明解释来自药物治疗方案复杂或定义不明确的研究数据存在困难。
