Steer A C, Jenney A J W, Oppedisano F, Batzloff M R, Hartas J, Passmore J, Russell F M, Kado J H H, Carapetis J R
Centre for International Child Health, University of Melbourne, Victoria, Australia.
Epidemiol Infect. 2008 May;136(5):621-7. doi: 10.1017/S095026880700917X. Epub 2007 Jul 16.
We undertook a 5-year retrospective study of group A streptococcal (GAS) bacteraemia in Fiji, supplemented by a 9-month detailed retrospective study of beta-haemolytic streptococcal (BHS) infections. The all-age incidence of GAS bacteraemia over 5 years was 11.6/100,000. Indigenous Fijians were 4.7 times more likely to present with invasive BHS disease than people of other ethnicities, and 6.4 times more likely than Indo-Fijians. The case-fatality rate for invasive BHS infections was 28%. emm-typing was performed on 23 isolates: 17 different emm-types were found, and the emm-type profile was different from that found in industrialized nations. These data support the contentions that elevated rates of invasive BHS and GAS infections are widespread in developing countries, and that the profile of invasive organisms in these settings reflects a wide diversity of emm-types and a paucity of types typically found in industrialized countries.
我们对斐济的A组链球菌（GAS）菌血症进行了一项为期5年的回顾性研究，并辅以一项为期9个月的关于β溶血性链球菌（BHS）感染的详细回顾性研究。5年间GAS菌血症的全年龄发病率为11.6/10万。斐济原住民发生侵袭性BHS疾病的可能性是其他种族人群的4.7倍，是印度裔斐济人的6.4倍。侵袭性BHS感染的病死率为28%。对23株分离株进行了emm分型：发现了17种不同的emm型，其emm型谱与工业化国家不同。这些数据支持了以下观点：侵袭性BHS和GAS感染的高发病率在发展中国家广泛存在，并且这些环境中的侵袭性生物体谱反映了emm型的广泛多样性以及工业化国家中常见类型的稀缺性。
