Yamaguchi Taihei, Osamura Naoki, Zhao Chunfeng, Zobitz Mark E, An Kai-Nan, Amadio Peter C
Division of Orthopedic Research, Department of Orthopedic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
J Biomech. 2008 Dec 5;41(16):3519-22. doi: 10.1016/j.jbiomech.2007.06.004. Epub 2007 Jul 12.
The rabbit model is commonly used to study carpal tunnel syndrome (CTS). It has been proposed that the subsynovial connective tissue (SSCT) in the carpal tunnel may play a role in the etiology of CTS, but the material properties of the rabbit SSCT are unknown. The purpose of this study was to develop a method to measure the shear properties of the rabbit SSCT. In six rabbit cadaver forepaws, the excursion of the third digit flexor digitorum superficialis (FDS) and load to failure of the SSCT were measured in a custom device. The mean excursion to full flexion in this model was 7.08mm (S.D. 0.77). The mean shearing force at full flexion was 317 mN (S.D. 166). At full flexion percentage of maximum shear force in the SSCT was 54.5% (S.D. 19.4). The mean energy absorbed at full flexion was 0.29mJ (S.D. 0.31). The mean excursion needed to reach 5% of the maximum shear force was 3.04mm (S.D. 0.99). The testing model presented in this study demonstrates structural parameters to evaluate the shear properties of the SSCT in a rabbit model. The data presented could be used for estimating sample sizes in a more comprehensive study of the effect of CTS on the SSCT properties.
兔模型常用于研究腕管综合征（CTS）。有人提出腕管内的滑膜下结缔组织（SSCT）可能在CTS的病因中起作用，但兔SSCT的材料特性尚不清楚。本研究的目的是开发一种测量兔SSCT剪切特性的方法。在六只兔尸体前爪中，在定制装置中测量第三指浅屈肌（FDS）的偏移和SSCT的破坏载荷。该模型中完全屈曲的平均偏移为7.08mm（标准差0.77）。完全屈曲时的平均剪切力为317mN（标准差166）。完全屈曲时SSCT中最大剪切力的百分比为54.5%（标准差19.4）。完全屈曲时吸收的平均能量为0.29mJ（标准差0.31）。达到最大剪切力5%所需的平均偏移为3.04mm（标准差0.99）。本研究中提出的测试模型展示了评估兔模型中SSCT剪切特性的结构参数。所呈现的数据可用于在更全面研究CTS对SSCT特性影响时估计样本量。
