Satterthwaite Theodore D, Green Leonard, Myerson Joel, Parker Jamie, Ramaratnam Mohana, Buckner Randy L
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
Neuroimage. 2007 Sep 1;37(3):1017-31. doi: 10.1016/j.neuroimage.2007.04.066. Epub 2007 May 24.
Decision making involves the allocation of cognitive resources in response to expectations and feedback. Here we explored how frontal networks respond in a gambling paradigm in which uncertainty was manipulated to increase demands for cognitive control. In one experiment, pupil diameter covaried with uncertainty during decision making and with the degree to which subsequent outcomes violated reward expectations. In a second experiment, fMRI showed that both uncertainty and unexpected outcomes modulated activation in a network of frontal regions. Thus, the frontal network supports multiple phases of the decision-making process including information regarding reward uncertainty and reward outcome. In contrast, striatal activation only tracked reward delivery, suggesting a distinct reward pathway that might, under certain circumstances, oppose the frontal network. These results are consistent with the interpretation that reward signals may bias recruitment of frontal networks that are linked to allocation of cognitive resources.
决策涉及根据期望和反馈分配认知资源。在此，我们探讨了额叶网络在赌博范式中的反应，其中不确定性被操纵以增加对认知控制的需求。在一项实验中，瞳孔直径在决策过程中与不确定性以及随后结果违反奖励期望的程度相关。在第二项实验中，功能磁共振成像显示不确定性和意外结果均调节额叶区域网络的激活。因此，额叶网络支持决策过程的多个阶段，包括有关奖励不确定性和奖励结果的信息。相比之下，纹状体激活仅跟踪奖励发放，表明存在一条独特的奖励通路，在某些情况下可能与额叶网络相反。这些结果与奖励信号可能使与认知资源分配相关的额叶网络的募集产生偏差这一解释一致。
