RNA聚合酶II：只是路过。

RNA polymerase II: just stopping by.

作者信息

Lorincz Matthew C, Schübeler Dirk

机构信息

Department of Medical Genetics, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.

出版信息

Cell. 2007 Jul 13;130(1):16-8. doi: 10.1016/j.cell.2007.06.040.

DOI:10.1016/j.cell.2007.06.040

PMID:17632051

Abstract

In this issue of Cell, Guenther et al. (2007) analyze the presence of chromatin marks and RNA polymerase at transcription start sites in the human genome. Their results reveal that many "inactive" genes harbor histone marks associated with active transcription at their 5' ends and that although these genes initiate transcription, they do not generate full-length transcripts.

摘要

在本期《细胞》杂志中，京特等人（2007年）分析了人类基因组中转录起始位点处染色质标记和RNA聚合酶的存在情况。他们的结果显示，许多“沉默”基因在其5'端含有与活跃转录相关的组蛋白标记，并且尽管这些基因起始转录，但它们并未产生全长转录本。