RNA聚合酶II转录的非编码RNA调控因子
Non-coding-RNA regulators of RNA polymerase II transcription.
作者信息
Goodrich James A, Kugel Jennifer F
机构信息
Department of Chemistry and Biochemistry, University of Colorado at Boulder, 215 UCB, Boulder, Colorado 80309-0215, USA.
出版信息
Nat Rev Mol Cell Biol. 2006 Aug;7(8):612-6. doi: 10.1038/nrm1946. Epub 2006 May 24.
DOI:10.1038/nrm1946
PMID:16723972
Abstract
Several non-coding RNAs (ncRNAs) that regulate eukaryotic mRNA transcription have recently been discovered. Their mechanisms of action and biological roles are extremely diverse, which indicates that, so far, we have only had a glimpse of this new class of regulatory factor. Many surprises are likely to be revealed as further ncRNA transcriptional regulators are identified and characterized.
摘要
最近发现了几种调控真核生物mRNA转录的非编码RNA（ncRNA）。它们的作用机制和生物学功能极为多样，这表明到目前为止，我们只是初步了解了这类新的调控因子。随着更多的ncRNA转录调节因子被鉴定和表征，可能会揭示出许多令人惊讶的发现。
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