蛋白磷酸酶2A：揭示一种“不情愿”的肿瘤抑制因子

PP2A: unveiling a reluctant tumor suppressor.

作者信息

Mumby Marc

机构信息

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

出版信息

Cell. 2007 Jul 13;130(1):21-4. doi: 10.1016/j.cell.2007.06.034.

DOI:10.1016/j.cell.2007.06.034

PMID:17632053

Abstract

Although evidence has suggested that the serine/threonine protein phosphatase 2A (PP2A) might be a tumor suppressor protein, it has been difficult to pin down its role in tumor suppression because it acts in a wide variety of signaling pathways. Recent findings, including work in this issue by Junttila et al. (2007), provide convincing evidence that suppression of PP2A activity cooperates with other oncogenic changes to cause transformation of multiple cell types.

摘要

尽管有证据表明丝氨酸/苏氨酸蛋白磷酸酶2A（PP2A）可能是一种肿瘤抑制蛋白，但由于它在多种信号通路中发挥作用，因此很难确定其在肿瘤抑制中的作用。最近的研究发现，包括Junttila等人（2007年）在本期发表的研究成果，提供了令人信服的证据，表明PP2A活性的抑制与其他致癌变化协同作用，导致多种细胞类型发生转化。