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DREAM复合物在癌症中的新作用及治疗机会

Emerging Role of the DREAM Complex in Cancer and Therapeutic Opportunities.

作者信息

Hwang Ye-Jin, Kim Moon Jong

机构信息

Department of Life Science, Gachon University, Seongnam 13120, Republic of Korea.

Department of Health Science and Technology, GAIHST, Lee Gil Ya Cancer and Diabetes Institute, Incheon 21999, Republic of Korea.

出版信息

Int J Mol Sci. 2025 Jan 1;26(1):322. doi: 10.3390/ijms26010322.

DOI:10.3390/ijms26010322
PMID:39796178
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11719884/
Abstract

The DREAM (dimerization partner, RB-like, E2F, and multi-vulval class B) complex is an evolutionarily conserved transcriptional repression complex that coordinates nearly one thousand target genes, primarily associated with the cell cycle processes. The formation of the DREAM complex consequently inhibits cell cycle progression and induces cellular quiescence. Given its unique role in cell cycle control, the DREAM complex has gained significant interest across various physiological and pathological contexts, particularly in conditions marked by dysregulated cell cycles, such as cancer. However, the specific cancer types most significantly affected by alterations in the DREAM complex are yet to be determined. Moreover, the possibility of restoring or pharmacologically targeting the DREAM complex as a therapeutic intervention against cancer remains a relatively unexplored area of research and is currently under active investigation. In this review, we provide an overview of the latest advances in understanding the DREAM complex, focusing on its role in cancer. We also explore strategies for targeting the DREAM complex as a potential approach for cancer therapeutics. Advances in understanding the precise role of the DREAM complex in cancer, combined with ongoing efforts to develop targeted therapies, may pave the way for new options in cancer therapy.

摘要

DREAM（二聚化伴侣、RB样、E2F和多外阴B类）复合物是一种进化上保守的转录抑制复合物，它协调近千个靶基因，主要与细胞周期进程相关。因此，DREAM复合物的形成会抑制细胞周期进程并诱导细胞静止。鉴于其在细胞周期控制中的独特作用，DREAM复合物在各种生理和病理背景下都引起了极大的关注，特别是在细胞周期失调的情况下，如癌症。然而，受DREAM复合物改变影响最显著的具体癌症类型尚未确定。此外，将恢复或通过药物靶向DREAM复合物作为抗癌治疗干预措施的可能性仍是一个相对未被探索的研究领域，目前正在积极研究中。在这篇综述中，我们概述了在理解DREAM复合物方面的最新进展，重点关注其在癌症中的作用。我们还探讨了将靶向DREAM复合物作为癌症治疗潜在方法的策略。对DREAM复合物在癌症中精确作用的理解进展，结合正在进行的开发靶向治疗的努力，可能为癌症治疗开辟新的选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3493/11719884/bf4698f2d838/ijms-26-00322-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3493/11719884/62f6881156b5/ijms-26-00322-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3493/11719884/3133d9fe5207/ijms-26-00322-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3493/11719884/bf4698f2d838/ijms-26-00322-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3493/11719884/62f6881156b5/ijms-26-00322-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3493/11719884/3133d9fe5207/ijms-26-00322-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3493/11719884/bf4698f2d838/ijms-26-00322-g003.jpg

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Cancer Cell. 2024 Nov 11;42(11):1983. doi: 10.1016/j.ccell.2024.10.013.
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PCLAF-DREAM drives alveolar cell plasticity for lung regeneration.PCLAF-DREAM 驱动肺泡细胞可塑性实现肺再生。
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Nucleic Acids Res. 2024 Jul 8;52(12):6945-6963. doi: 10.1093/nar/gkae426.
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Inhibition of the YAP-MMB interaction and targeting NEK2 as potential therapeutic strategies for YAP-driven cancers.抑制 YAP-MMB 相互作用和靶向 NEK2 作为 YAP 驱动型癌症的潜在治疗策略。
Oncogene. 2024 Feb;43(8):578-593. doi: 10.1038/s41388-023-02926-w. Epub 2024 Jan 5.
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