Corbellini G, Ribatti D
Dipartimento di Genetica e Biologia molecolare, Facoltà di Scienze matematiche, fisiche e naturali, Università La Sapienza, Roma.
Recenti Prog Med. 1991 Nov;82(11):611-7.
The description of agammaglobulinemia by O. Bruton in 1952 and later clinical studies by R. Good preceeded by sporadic clinical observations on deficits in the immune function associated with hyponutrition, nephrosis and tumors or with inborn errors of metabolism have all made their contribution to the emerging of the concept of immunological deficiency diseases. The clinical-pathogenetic description of immunological deficiency diseases has played a fundamental role in the understanding of the anatomo-functional bases of the immune system and research work on the phylogenetic and ontogenetic evolution of the immune response. Various methodologies, from the idea of experimentum naturae to molecular pathology, combine to define and direct this research, the result of an ongoing interaction between the hospital and the laboratory. This leads to a necessary theoretical-practical synthesis and contributes to the consolidation of an immunologically-directed medicine.
1952年O. 布鲁顿对无丙种球蛋白血症的描述以及后来R. 古德的临床研究，此前关于与营养不良、肾病、肿瘤相关的免疫功能缺陷或先天性代谢错误的零星临床观察，都为免疫缺陷疾病概念的出现做出了贡献。免疫缺陷疾病的临床发病机制描述在理解免疫系统的解剖功能基础以及免疫反应的系统发生和个体发生进化研究方面发挥了基础性作用。从自然实验理念到分子病理学的各种方法相结合，来定义和指导这项研究，这是医院和实验室之间持续互动的结果。这导致了必要的理论与实践的综合，并有助于巩固以免疫为导向的医学。
