Rouas-Freiss Nathalie, Naji Abderrahim, Durrbach Antoine, Carosella Edgardo D
Service de Recherches en Hémato-Immunologie, CEA-DSV-DRM, Hôpital Saint-Louis, Institut Universitaire d'Hématologie, 1 Avenue Claude Vellefaux, 75010 Paris, France.
Transplantation. 2007 Jul 15;84(1 Suppl):S21-5. doi: 10.1097/01.tp.0000269117.32179.1c.
Over the past few years, the number of publications concerning the human leukocyte antigen (HLA)-G molecule, its functions, and its pathological implications has greatly increased, largely exceeding those focusing simply on fetal-maternal activity. The role of this molecule in other situations of tolerance such as transplantation, tumor dissemination, or virus infections has also been reported. In this paper, we focus our attention on the relevance of HLA-G in transplantation in the light of recent data associating regulatory T cells and HLA-G, and which provide evidence of the role of HLA-G in improving graft acceptance.
在过去几年中，关于人类白细胞抗原（HLA）-G分子、其功能及其病理意义的出版物数量大幅增加，大大超过了仅关注胎儿-母体活动的文献数量。该分子在其他免疫耐受情况（如移植、肿瘤扩散或病毒感染）中的作用也有报道。在本文中，鉴于最近将调节性T细胞与HLA-G相关联的数据，这些数据为HLA-G在提高移植物接受度中的作用提供了证据，我们将重点关注HLA-G在移植中的相关性。
