Stout Molly J, Cao Bin, Landeau Michele, French Jacob, Macones George A, Mysorekar Indira U
Department of Obstetrics and Gynecology and.
J Matern Fetal Neonatal Med. 2015 Mar;28(4):454-9. doi: 10.3109/14767058.2014.921152. Epub 2014 May 29.
Abstract Objective: The maternal-fetal interface must modulate immune function to allow tolerance of fetal cells while still reacting to pathogens to suppress infection. Human leukocyte antigen-G (HLA-G) is a class Ib major histocompatibility complex protein involved in maternal-fetal tolerance. We posited that alterations in placental HLA-G expression predispose women to preterm birth. The aim of this study was to compare HLA-G expression in the maternal-fetal interface of term versus preterm human placentas.
We performed a cross-sectional study of specimens from the basal plate of the human placenta from women enrolled in a tissue specimen and clinical data consortium. Immunohistochemistry with digital microscopic analysis was used to quantify HLA-G protein expression in the basal plate from preterm and term placentas.
Preterm birth <37 weeks occurred in 29.5% of 149 singleton pregnancies. HLA-G-positive cells occupied one-third of the basal plates, and the HLA-G-positive area was increased by 14% in placentas from preterm births than in those from term births (32.1% in term placentas versus 36.6% in preterm placentas).
Although HLA-G is required for maternal tolerance of the semi-allogeneic fetus, higher levels of HLA-G expression at the maternal-fetal interface is associated with preterm birth.
摘要 目的：母胎界面必须调节免疫功能，以允许对胎儿细胞产生耐受性，同时仍能对病原体作出反应以抑制感染。人类白细胞抗原G（HLA - G）是一种参与母胎耐受的Ib类主要组织相容性复合体蛋白。我们推测胎盘HLA - G表达的改变使女性易发生早产。本研究的目的是比较足月与早产人类胎盘母胎界面中HLA - G的表达。
我们对参与组织标本和临床数据联盟的女性的人胎盘基底板标本进行了横断面研究。采用免疫组织化学结合数字显微镜分析来量化早产和足月胎盘基底板中HLA - G蛋白的表达。
149例单胎妊娠中，29.5%发生了<37周的早产。HLA - G阳性细胞占基底板的三分之一，早产胎盘的HLA - G阳性面积比足月胎盘增加了14%（足月胎盘为32.1%，早产胎盘为36.6%）。
尽管HLA - G是母胎对半同种异体胎儿产生耐受性所必需的，但母胎界面处较高水平的HLA - G表达与早产有关。
