Ribeiro J, Ericson D
Department of Cariology, Faculty of Odontology, Lund University, Malmö, Sweden.
Scand J Dent Res. 1991 Dec;99(6):533-40. doi: 10.1111/j.1600-0722.1991.tb01066.x.
The aims of the present study were to investigate the antibacterial properties of glass-ionomer cements containing different concentrations of chlorhexidine and the possible release of chlorhexidine from the compound. Chlorhexidine gluconate or diacetate was mixed with glass-ionomer cements and tested in vitro against strains of Lactobacillus casei and mutans streptococci. A spectrophotometric test was used to monitor the release of chlorhexidine from the mixture. In a broth culture test, the higher the concentrations of chlorhexidine in the mixture, the longer the time of antibacterial effect on Streptococcus mutans and the greater the tendency of the material to deteriorate. Agar diffusion tests revealed bacterial inhibition in a dose-response manner. The tested bacterial strains were similarly inhibited and the antibacterial properties decreased with time. A minor portion of added chlorhexidine was released from the cement. The deterioration of the cements indicates that the material could be useful as a varnish-like chlorhexidine carrier.
本研究的目的是调查含有不同浓度氯己定的玻璃离子水门汀的抗菌性能以及氯己定从该化合物中的可能释放情况。葡萄糖酸氯己定或二醋酸氯己定与玻璃离子水门汀混合，并在体外针对干酪乳杆菌和变形链球菌菌株进行测试。使用分光光度法测试来监测氯己定从混合物中的释放。在肉汤培养试验中，混合物中氯己定的浓度越高，对变形链球菌的抗菌作用时间越长，且材料变质的趋势越大。琼脂扩散试验显示出剂量反应方式的细菌抑制作用。受试菌株受到类似抑制，且抗菌性能随时间下降。添加的氯己定有一小部分从水门汀中释放出来。水门汀的变质表明该材料可用作类似清漆的氯己定载体。
