Søndenaa K, Nesvik I, Nygaard K, Sauer T
Dept. of Surgery, Rogaland Central County Hospital, Stavanger, Norway.
Scand J Gastroenterol. 1991 Dec;26(12):1240-6. doi: 10.3109/00365529108998620.
Only scarce knowledge exists of morphologic changes after antiperistaltic reversal of the small intestine. Previous animal models using a reversed segment of the small intestine after massive intestinal resection have been mostly concerned with assessing absorption. A rat model was therefore developed for the purpose of studying mucosal surface area in the small intestine after reversal of an intestinal segment. A reversal of 10 cm, representing a length of about 10%, was found suitable for the investigation. Marked dilatation of the reversed segment occurred. A pronounced increase in mucosal surface area caused by mucosal hyperplasia was observed. The mucosal surface area in an anastomosed, but not reversed, segment also increased markedly compared with a group undergoing no operation, although less than in the reversed segment. We conclude that a reversed intestinal segment will increase mucosal surface area in an optimal length used for this purpose. This increase is possibly caused by prolonged exposure to intestinal chyme.
关于小肠反蠕动翻转后的形态学变化，目前仅有稀缺的知识。以往使用大量肠切除术后小肠反转节段的动物模型大多关注吸收情况。因此，为了研究肠段翻转后小肠的黏膜表面积，开发了一种大鼠模型。发现10厘米的翻转长度（约占肠管长度的10%）适合该研究。翻转节段出现明显扩张。观察到由黏膜增生导致的黏膜表面积显著增加。与未进行手术的组相比，吻合但未翻转节段的黏膜表面积也显著增加，尽管增幅小于翻转节段。我们得出结论，用于此目的的最佳长度的翻转肠段会增加黏膜表面积。这种增加可能是由于长时间接触肠内容物所致。
